4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid

Base Information

Chemical Name:4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid
CAS No.:943345-28-6
Molecular Formula:C₂₉H₂₅N₃O₄
Molecular Weight:479.535
Hs Code.:

Synonyms:4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid

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Chemical Property of 4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid

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Technology Process of 4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid

There total 6 articles about 4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.2%

: 943345-27-5
4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester

: 943345-28-6
4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid

Guidance literature:: 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; at 20 - 50 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 67857-97-0
4-(2-nitrophenyl)-n-butyric acid

: 943345-28-6
4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

3: 150 °C

4: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

With thionyl chloride; water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;

Reference yield:

: 22824-20-0
4(2-nitrophenyl)butanoic acid methyl ester

: 943345-28-6
4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

2: 150 °C

3: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

With water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;