67857-97-0

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Nitro-phenyl)-butyric acid is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds, contributing to the development of new drugs and therapeutic agents.
Used in Anti-inflammatory and Analgesic Applications:
Leveraging its anti-inflammatory and analgesic properties, 4-(2-Nitro-phenyl)-butyric acid is used as a potential treatment for chronic pain, inflammation, and related conditions, offering relief and managing symptoms effectively.
Used in Neurological Disorder Treatment:
4-(2-Nitro-phenyl)-butyric acid is being investigated for its potential role in treating neurological disorders such as epilepsy and depression, suggesting its capacity to address a range of neurological health issues.

InChI:InChI=1/C10H11NO4/c12-10(13)7-3-5-8-4-1-2-6-9(8)11(14)15/h1-2,4,6H,3,5,7H2,(H,12,13)

Upstream product

• 67857-98-1 <2-(o-Nitro-phenyl)aethyl>malonsaeure 
• 1821-12-1 4-Phenylbutyric acid 
• 108-24-7 acetic anhydride 
• 28917-41-1 1-(2-chloroethyl)-2-nitrobenzene 
• 90915-20-1 4-(2-nitrophenyl)-n-butyronitril 

Downstream Products

• 22824-20-0 4(2-nitrophenyl)butanoic acid methyl ester 
• 20637-02-9 methyl 4-(4-nitrophenyl)butanoate 
• 20637-09-6 methyl 4-(4-aminophenyl)butanoate 
• 46320-17-6 4-(2-aminophenyl)butanoic acid methyl ester 
• 943345-28-6 4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid 
• 943345-27-5 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester 
• 630105-96-3 4-(2-nitrophenyl)-n-butyric acid chloride 
• 51114-73-9 5-nitro-1-tetralone 

Relevant academic research and scientific papers

Process for the preparation of 5-nitro-3,4-dihydro-1(2H)-naphthalenone, 1,5-naphthalendiamine and 1,5-naphthalendiisocyanate

A process for the production of 1,5-naphthalene diamine (I) comprises reaction of 4-(2-nitrophenyl)-n-butyronitrile to 4-(2-nitrophenyl)-n-butyric acid. Independent claims are included for: (1) a process for the production of 5-nitro-3,4-dihydro-1(2H)-naphthalinone by reaction of 4-(2-nitrophenyl)-n-butyronitrile to 4-(2-nitrophenyl)-n-butyric acid and; (2) a process for the production of 1,5-naphthalene diisocyanate by phosgenation of 1,5-naphthalene diamine (I).

Process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1-5-naphthalenediamine and 1,5-naphthalene diisocyanate

The present invention relates to a process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate, in which 4-(2-nitrophenyl)-n-butyronitrile is converted to 4-(2-nitrophenyl)-n-butyric acid.

Experiments on the Chaperon effect in the nitration of aromatics

A nitro group may be effectively delivered to the ortho position of alkylbenzenes, provided that a suitable chaperon function is located in α- position and a dilute of HNO3 in CH2Cl2 is used. The carbonyl function of an aldehyde or ketone is the best choice, but a carboxyl, alkoxycarbonyl, and amide groups all work well. The ether function showed a less pronounced ortho orientation effect, whereas the hydroxyl group was too prone to oxidation. Side reactions were minimal under the conditions employed. A para chaperon effect was seemingly at work in the CH2Cl2 nitration of benzenepropanenitrile. All the results were compared with the corresponding classical nitration in H2SO4.

1-Aryl-3-(2-chloroethyl) ureas: Synthesis and in vitro assay as potential anticancer agents

1-Aryl-3-(2-chlorethyl) ureas and 1-aryl-3-nitrose-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanillines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitrose derivatives were inactive.