4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester

Base Information

• Chemical Name: 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester
• CAS No.: 943345-27-5
• Molecular Formula: C₃₀H₂₇N₃O₄
• Molecular Weight: 493.562
• Mol file: 943345-27-5.mol

Synonyms:4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester

Chemical Property of 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester

There total 6 articles about 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.7%

4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine (943230-31-7) + 4-(2-aminophenyl)butanoic acid methyl ester (46320-17-6) → 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester (943345-27-5)

Guidance literature:

at 150 ℃;

Reference yield:

4-(2-nitrophenyl)-n-butyric acid (67857-97-0) → 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester (943345-27-5)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

3: 150 °C

With thionyl chloride; hydrogen; palladium 10% on activated carbon; In ethanol;

Reference yield:

4(2-nitrophenyl)butanoic acid methyl ester (22824-20-0) → 4-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester (943345-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

2: 150 °C

With hydrogen; palladium 10% on activated carbon; In ethanol;

upstream raw materials:

4-(2-nitrophenyl)-n-butyric acid

4-methoxybenzoin

4(2-nitrophenyl)butanoic acid methyl ester

2-amino-4-(4-methoxyphenyl)-5-phenylfuran-3-carbonitrile

Downstream raw materials:

4-(2-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid