(R)-Norfluoxetine

Base Information

Chemical Name:(R)-Norfluoxetine
CAS No.:130194-43-3
Molecular Formula:C16H16 F3 N O
Molecular Weight:295.304
Hs Code.:
European Community (EC) Number:808-828-1
UNII:05UQ1299DN
Nikkaji Number:J511.687B
Wikidata:Q27236142
Pharos Ligand ID:9V25WZXNJZ7M
ChEMBL ID:CHEMBL446084
Mol file:130194-43-3.mol

Synonyms:(R)-Norfluoxetine;130194-43-3;Norfluoxetine, (R)-;(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine;(3r)-3-Phenyl-3-[4-(Trifluoromethyl)phenoxy]propan-1-Amine;UNII-05UQ1299DN;(R)-3-(4-Trifluoromethylphenoxy)-3-phenylpropylamine;05UQ1299DN;CHEMBL446084;Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-, (gammaR)-;Benzenepropanamine, gamma-[4-(trifluoromethyl)phenoxy]-, (gammaR)-;R-Norfluoxetine;D02ENH;SCHEMBL3750512;WIQRCHMSJFFONW-OAHLLOKOSA-N;BDBM50254791;AKOS027384575;J-005760;Q27236142;(R)-3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine;(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine, AldrichCPR;BENZENEPROPANAMINE, .GAMMA.-(4-(TRIFLUOROMETHYL)PHENOXY)-, (.GAMMA.R)-

Suppliers and Price of (R)-Norfluoxetine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Norfluoxetine
25mg
$ 1455.00

SynQuest Laboratories
1-[(1R)-3-Amino-1-phenylpropoxy]-4-(trifluoromethyl)benzene 96%
1 g
$ 1595.00

SynQuest Laboratories
1-[(1R)-3-Amino-1-phenylpropoxy]-4-(trifluoromethyl)benzene 96%
250 mg
$ 593.00

J&W Pharmlab
(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine 96%
5g
$ 6990.00

J&W Pharmlab
(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine 96%
1g
$ 1880.00

J&W Pharmlab
(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine 96%
500mg
$ 998.00

J&W Pharmlab
(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine 96%
100mg
$ 325.00

J&W Pharmlab
(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine 96%
50mg
$ 212.00

J&W Pharmlab
(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine 96%
250mg
$ 549.00

American Custom Chemicals Corporation
(R)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE 98.00%
5MG
$ 497.90

Total 9 raw suppliers

Chemical Property of (R)-Norfluoxetine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.526
Boiling Point:381.069°C at 760 mmHg
Flash Point:184.264°C
PSA：35.25000
Density:1.205g/cm³
LogP:4.87460
Storage Temp.:Hygroscopic, -20?C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:295.11839862
Heavy Atom Count:21
Complexity:294

Purity/Quality:

97% ^*data from raw suppliers

(R)-Norfluoxetine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(CCN)OC2=CC=C(C=C2)C(F)(F)F
Isomeric SMILES:C1=CC=C(C=C1)[C@@H](CCN)OC2=CC=C(C=C2)C(F)(F)F
Uses As a metabolite of Fluoxetine, a selective serotonin reuptake inhibitor (R)-Norfluoxetine is used as an antidepressant.

Technology Process of (R)-Norfluoxetine

There total 14 articles about (R)-Norfluoxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 98-56-6
4-chlorobenzotrifluoride

: 138750-31-9
(1R)-3-amino-1-phenyl-1-propanol

: 130194-43-3,56161-73-0
(R)-Norfluoxetine

Guidance literature:: (1R)-3-amino-1-phenyl-1-propanol; With sodium hydride; In dimethyl sulfoxide; at 55 ℃; for 0.5h;

4-chlorobenzotrifluoride; In dimethyl sulfoxide; at 90 ℃; for 1h;
DOI:10.1016/S0040-4039(02)00842-0