2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

Base Information

Chemical Name:2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide
CAS No.:1246373-17-0
Molecular Formula:C₂₀H₁₃F₂N₇O₃S₂
Molecular Weight:501.497
Hs Code.:

Synonyms:2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

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Chemical Property of 2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

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Technology Process of 2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

There total 4 articles about 2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 863422-41-7
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridazine

: 1246373-16-9
2,4-difluoro-N-[2-methoxy-5-(5-iodoimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

: 1246373-17-0
2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; for 42h; Reflux; Inert atmosphere;

Reference yield:

: 893440-50-1
2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine

: 1246373-17-0
2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C / Inert atmosphere

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 3 h / Inert atmosphere; Reflux

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 42 h / Reflux; Inert atmosphere

With pyridine; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; 2: Suzuki Coupling / 3: Suzuki Coupling;

Reference yield:

: 884495-39-0
5-bromo-2-(methyloxy)-3-pyridinamine

: 1246373-17-0
2,4-difluoro-N-[2-methoxy-5-(5-pyridazin-4-yl-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

2: pyridine / 20 °C / Inert atmosphere

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 3 h / Inert atmosphere; Reflux

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 42 h / Reflux; Inert atmosphere

With pyridine; potassium acetate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide; 3: Suzuki Coupling / 4: Suzuki Coupling;