(R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

Base Information

Chemical Name:(R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide
CAS No.:1255700-78-7
Molecular Formula:C₂₈H₃₀N₆O₃
Molecular Weight:498.585
Hs Code.:

Synonyms:(R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

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Chemical Property of (R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

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Technology Process of (R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

There total 5 articles about (R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 958245-18-6
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

: 1255701-71-3
(R)-8-chloro-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

: 1255700-78-7
(R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

Guidance literature:: With caesium carbonate; palladium diacetate; CyJohnPhos; In 1,2-dimethoxyethane; at 100 ℃; for 4h; Inert atmosphere; Capped microwave vial;

Reference yield:

: 41789-37-1
2,6-dichloro-5-pyridylmethyl chloride

: 1255700-78-7
(R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

4: caesium carbonate / palladium diacetate; CyJohnPhos / 1,2-dimethoxyethane / 4 h / 100 °C / Inert atmosphere; Capped microwave vial

With sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; CyJohnPhos; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1255701-25-7
(R)-8-chloro-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine

: 1255700-78-7
(R)-8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-N,N-dimethyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2: caesium carbonate / palladium diacetate; CyJohnPhos / 1,2-dimethoxyethane / 4 h / 100 °C / Inert atmosphere; Capped microwave vial

With caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; CyJohnPhos; In 1,2-dimethoxyethane; dichloromethane;