N-[(4-Methylphenyl)methyl]-N-(piperidin-4-yl)-2-phenylacetamide

Base Information

Chemical Name:N-[(4-Methylphenyl)methyl]-N-(piperidin-4-yl)-2-phenylacetamide
CAS No.:359878-01-6
Molecular Formula:C₂₁H₂₆N₂O
Molecular Weight:322.45
Hs Code.:
DSSTox Substance ID:DTXSID701175592

Synonyms:SCHEMBL341661;DTXSID701175592;N-[(4-Methylphenyl)methyl]-N-(piperidin-4-yl)-2-phenylacetamide;359878-01-6

Suppliers and Price of N-[(4-Methylphenyl)methyl]-N-(piperidin-4-yl)-2-phenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(4-Methylphenyl)methyl]-N-(piperidin-4-yl)-2-phenylacetamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:322.204513457
Heavy Atom Count:24
Complexity:377

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)CN(C2CCNCC2)C(=O)CC3=CC=CC=C3

Technology Process of N-[(4-Methylphenyl)methyl]-N-(piperidin-4-yl)-2-phenylacetamide

There total 4 articles about N-[(4-Methylphenyl)methyl]-N-(piperidin-4-yl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₄N₂O₃

: 359878-01-6
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)phenylacetamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 2h;

Reference yield:

: 359877-52-4
tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate

: 359878-01-6
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; diethyl ether; dichloromethane;

Reference yield:

: 104-84-7
para-methylbenzylamine

: 359878-01-6
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium cyanoborohydride / methanol / 20 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;