N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-N^α-(benzyloxycarbonyl)glycinamide

Base Information

• Chemical Name: N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-N^α-(benzyloxycarbonyl)glycinamide
• CAS No.: 512168-91-1
• Molecular Formula: C₆₂H₉₈N₂O₈Si
• Molecular Weight: 1027.55
• Mol file: 512168-91-1.mol

Synonyms:N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-N^α-(benzyloxycarbonyl)glycinamide

Chemical Property of N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-N^α-(benzyloxycarbonyl)glycinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-N^α-(benzyloxycarbonyl)glycinamide

There total 5 articles about N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-N^α-(benzyloxycarbonyl)glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-[1,1-bis(hydroxymethyl)-2-(t-butyldiphenylsilyloxymethyl)ethyl]-Nα-(benzyloxycarbonyl)glycinamide (512168-90-0) + n-hexadecanoyl chloride (112-67-4) → N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-Nα-(benzyloxycarbonyl)glycinamide (512168-91-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1071/CH02124

Reference yield:

N-(2,2-dimethyl-5-hydroxymethyl-[1,3]dioxan-5-yl)-Nα-(benzyloxycarbonyl)glycinamide (223930-07-2) → N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-Nα-(benzyloxycarbonyl)glycinamide (512168-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / imidazole / dimethylformamide / 2.17 h / 0 - 20 °C

2: 83 percent / p-TsOH / acetone; H₂O / 12 h / Heating

3: 93 percent / DMAP; Et₃N / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; dmap; toluene-4-sulfonic acid; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1071/CH02124

Reference yield:

N-<2-hydroxy-1,1-bis(hydroxymethyl)ethyl>-Nα-(benzyloxycarbonyl)glycinamide (91202-74-3) → N-[1-t-butyldiphenylsilyloxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-Nα-(benzyloxycarbonyl)glycinamide (512168-91-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / CuSO₄; p-TsOH*H₂O / 36 h / 20 °C

2: 92 percent / imidazole / dimethylformamide / 2.17 h / 0 - 20 °C

3: 83 percent / p-TsOH / acetone; H₂O / 12 h / Heating

4: 93 percent / DMAP; Et₃N / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; dmap; toluene-4-sulfonic acid; copper(II) sulfate; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1071/CH02124

upstream raw materials:

N-[1,1-bis(hydroxymethyl)-2-(t-butyldiphenylsilyloxymethyl)ethyl]-N^α-(benzyloxycarbonyl)glycinamide

n-hexadecanoyl chloride

N-<2-hydroxy-1,1-bis(hydroxymethyl)ethyl>-N^α-(benzyloxycarbonyl)glycinamide

N-(2,2-dimethyl-5-hydroxymethyl-[1,3]dioxan-5-yl)-N^α-(benzyloxycarbonyl)glycinamide

Downstream raw materials:

N-[1-hydroxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]-N^α-(benzyloxycarbonyl)glycinamide