5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline

Base Information

Chemical Name:5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline
CAS No.:898530-60-4
Molecular Formula:C₁₇H₁₆Br₂N₂O₇S
Molecular Weight:552.197
Hs Code.:

Synonyms:5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline

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Chemical Property of 5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline

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Technology Process of 5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline

There total 7 articles about 5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5,8-dibromo-1-chloro-6,7-dimethoxy-2-(2-nitro-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline

: 898530-60-4
5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/ja0619455

Reference yield:

: 898530-75-1
5,8-dibromo-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

: 898530-60-4
5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 18.16 g / manganese oxide / CH₂Cl₂ / 18 h / 20 °C

2: tetrahydrofuran / 1.08 h / 0 - 20 °C

3: aq. sodium bicarbonate / tetrahydrofuran / 0.5 h / 20 °C

With manganese oxide; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0619455

Reference yield:

: 898530-74-0
1-(5,8-dibromo-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone

: 898530-60-4
5,8-dibromo-2-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-hydroxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / methanol; CH₂Cl₂ / 6 h / 20 °C

2: 18.16 g / manganese oxide / CH₂Cl₂ / 18 h / 20 °C

3: tetrahydrofuran / 1.08 h / 0 - 20 °C

4: aq. sodium bicarbonate / tetrahydrofuran / 0.5 h / 20 °C

With manganese oxide; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja0619455