2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester
CAS No.:815600-83-0
Molecular Formula:C₁₁H₁₀ClNO₂S
Molecular Weight:255.725
Hs Code.:

Synonyms:2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester

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Chemical Property of 2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester

There total 4 articles about 2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 40546-41-6
ethyl-4-chlorobenzimidate hydrochloride

: 815600-83-0
2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 72h;

Reference yield:

: 62096-94-0,61822-02-4
2-(4-chloro-phenyl)-4,5-dihydro-thiazole-4-carboxylic acid

: 74-88-4
methyl iodide

: 815600-83-0
2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1039/c2cc00081d

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 815600-83-0
2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / Reflux

2: acetic anhydride / Reflux

3: sodium hydrogencarbonate / ethanol; water

4: potassium hydrogencarbonate / N,N-dimethyl-formamide / 0 - 20 °C

With hydroxylamine hydrochloride; acetic anhydride; sodium hydrogencarbonate; sodium carbonate; potassium hydrogencarbonate; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c2cc00081d