40546-41-6

Basic information

• Product Name: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER
• Synonyms: ETHYL 4-CHLOROBENZIMIDATE HYDROCHLORIDE;4-Chloro-benzenecarboxiMidic Acid Ethyl Ether Hydrochloride;4-ChlorobenziMidoyl Ethyl Ether Hydrochloride;Ethyl p-ChlorobenziMidate Hydrochloride;4-Chlorobenzimidic acid ethyl ester hydrochloride;4-Chlorobenzimidic acid methyl ester hydrochloride;Methyl 4-chlorobenzimidate hydrochloride;Ethyl 4-chlorobenzenecarboximidate hydrochloride
• CAS NO: 40546-41-6
• Molecular Formula: C₉H₁₀ClNO*ClH
• Molecular Weight: 220.1
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 40546-41-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform
• CAS DataBase Reference: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER(40546-41-6)
• EPA Substance Registry System: 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER(40546-41-6)

Safety Data

• Hazardous Substances Data: 40546-41-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

4-Chlorobenzimidoyl Ethyl Ether Hydrochloride is a useful reagent in the synthesis of novel 3,5-disubstituted-1,2,4-triazoles and for evaluating antibacterial, antiurease and antioxidant activity.

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 75-36-5 acetyl chloride 
• 64-17-5 ethanol 
• 3848-36-0 4-chlorobenzaldoxime 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 82380-75-4 2-((1H-indol-3-yl)methyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole 
• 1333221-42-3 methyl 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate 
• 300800-07-1 methyl 2-(4-chlorophenyl)-1,3-oxazole-4-carboxylate 
• 1370731-53-5 methyl 2-(p-chlorophenyl)-5-phenyloxazole-4-carboxylate 
• 1370731-54-6 C₂₂H₁₄Cl₂N₂O₆ 
• 1617508-83-4 2,4-dichloro-5-[5-(4-chlorophenyl)-1,2,4-triazol-3-yl]benzenesulfonamide 
• 19563-04-3 p-chlorobenzamidine 
• 827-72-5 4-chlorobenzimidic acid ethyl ester 
• 56107-76-7 3-(4-chlorophenyl)-6-methyl-1,2,4,5-tetrazine 
• 143703-90-6 ethyl p-chlorobenzoate 4-pyridinoylhydrazone 
• 14401-51-5 4-chlorobenzamidine hydrochloride 
• 815600-83-0 2-(4-chlorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid methyl ester 

Relevant articles and documents

DNA-Encoded Libraries: Hydrazide as a Pluripotent Precursor for On-DNA Synthesis of Various Azole Derivatives

DNA-encoded combinatorial chemical library (DEL) technology, an approach that combines the power of genetics and chemistry, has emerged as an invaluable tool in drug discovery. Skeletal diversity plays a fundamental importance in DEL applications, and relies heavily on novel DNA-compatible chemical reactions. We report herein a phylogenic chemical transformation strategy using DNA-conjugated benzoyl hydrazine as a common versatile precursor in azole chemical expansion of DELs. DNA-compatible reactions deriving from the common benzoyl hydrazine precursor showed excellent functional group tolerance with exceptional efficiency in the synthesis of various azoles, including oxadiazoles, thiadiazoles, and triazoles, under mild reaction conditions. The phylogenic chemical transformation strategy provides DELs a facile way to expand into various unique chemical spaces with privileged scaffolds and pharmacophores.

Colchicine derivatives, and preparation method and medical application thereof

The invention specifically relates to colchicine derivatives (I) as described in the specification and a preparation method thereof, and pharmaceutical compositions containing the colchicine derivatives, belonging to the field of medicinal chemistry. The results of pharmacodynamic experiments prove that the colchicine derivatives of the invention have treatment effect on lumbar disc herniation andliver fibrosis.

Pd(ii)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage

The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance. The Royal Society of Chemistry 2012.