benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

Base Information

Chemical Name:benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide
CAS No.:81092-92-4
Molecular Formula:C₃₀H₄₀N₄O₇S
Molecular Weight:600.736
Hs Code.:

Synonyms:benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

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Chemical Property of benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

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Technology Process of benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

There total 4 articles about benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 47307-26-6,149967-07-7
(S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester

: 81092-92-4
benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / dicyclohexylcarbodiimide / ethyl acetate / 1.) 0 deg C, 0.5 h, 2.) RT, 12 h

2: 91 percent / diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / Ambient temperature

3: H₂ / 10percent Pd/C / ethanol; dimethylformamide

4: diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) RT

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00347a019

Reference yield:

: 6997-15-5
benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester

: 81092-92-4
benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol; dimethylformamide

3: diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) RT

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00347a019

Reference yield:

: 81092-90-2
benzyloxycarbonyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

: 81092-92-4
benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol; dimethylformamide

2: diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) RT

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00347a019