(S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

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Chemical Name:(S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester
CAS No.:81092-93-5
Molecular Formula:C₂₂H₃₄N₄O₅S
Molecular Weight:466.602
Hs Code.:

Synonyms:(S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

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Chemical Property of (S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

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Technology Process of (S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

There total 5 articles about (S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81092-92-4
benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

: 81092-93-5
(S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

Guidance literature:: With hydrogen; N-ethyl-N,N-diisopropylamine; Pd-BaSO₄; In water; N,N-dimethyl-formamide; for 12h;
DOI:10.1021/jm00347a019

Reference yield:

: 47307-26-6,149967-07-7
(S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester

: 81092-93-5
(S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / dicyclohexylcarbodiimide / ethyl acetate / 1.) 0 deg C, 0.5 h, 2.) RT, 12 h

2: 91 percent / diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / Ambient temperature

3: H₂ / 10percent Pd/C / ethanol; dimethylformamide

4: diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) RT

5: H₂, diisopropylethylamine (DIEA) / 10percent Pd/BaSO₄ / dimethylformamide; H₂O / 12 h

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; Pd-BaSO₄; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00347a019

Reference yield:

: 6997-15-5
benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester

: 81092-93-5
(S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol; dimethylformamide

3: diisopropylethylamine (DIEA), hydroxybenzotriazole (HOBt) / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) RT

4: H₂, diisopropylethylamine (DIEA) / 10percent Pd/BaSO₄ / dimethylformamide; H₂O / 12 h

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; Pd-BaSO₄; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00347a019