benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester

Base Information

• Chemical Name: benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester
• CAS No.: 6997-15-5
• Molecular Formula: C₂₂H₂₄N₂O₈
• Molecular Weight: 444.441
• Mol file: 6997-15-5.mol

Synonyms:benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester

Chemical Property of benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester

There total 2 articles about benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester (47307-26-6,149967-07-7) → benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester (6997-15-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; 1.) 0 deg C, 0.5 h, 2.) RT, 12 h;

DOI:10.1021/jm00347a019

Reference yield:

N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester (3160-47-2) → benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester (6997-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) H₂SO₄, (ii) (alkaline hydrolysis)

2: DCC

With dicyclohexyl-carbodiimide;

DOI:10.1021/jo01270a055

Reference yield: 91.0%

benzyloxycarbonyl-L-aspartic acid α-tert-butyl β-p-nitrophenyl ester (6997-15-5) + L-phenylalanine amide trifluoroacetate (81092-89-9) → benzyloxycarbonyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide (81092-90-2)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00347a019

upstream raw materials:

4-nitro-phenol

(S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester

N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester

Downstream raw materials:

benzyloxycarbonyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide

(S)-2-Amino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

(S)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

benzyloxycarbonyl-L-methionyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide