3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene-7,15-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene-7,15-dicarboxylic acid diethyl ester
• CAS No.: 223450-18-8
• Molecular Formula: C₃₆H₃₈N₂O₈S₂
• Molecular Weight: 690.838
• Mol file: 223450-18-8.mol

Synonyms:3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene-7,15-dicarboxylic acid diethyl ester

Chemical Property of 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene-7,15-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene-7,15-dicarboxylic acid diethyl ester

There total 3 articles about 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene-7,15-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3,5-bis[bromomethyl]benzoic acid ethyl ester (146085-71-4) + 3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester (223450-04-2) → 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.15,9]octadeca-1(17),5,7,9(18),13,15-hexaene-7,15-dicarboxylic acid diethyl ester (223450-18-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1055/s-1999-3385

Reference yield:

benzyl N-(4-methylbenzenesulfonyl)carbamate (18303-10-1) → 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.15,9]octadeca-1(17),5,7,9(18),13,15-hexaene-7,15-dicarboxylic acid diethyl ester (223450-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 72 h

2: 60 percent / K₂CO₃ / dimethylformamide / 72 h / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1055/s-1999-3385

Reference yield:

3,5-bis[bromomethyl]benzoic acid ethyl ester (146085-71-4) → 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.15,9]octadeca-1(17),5,7,9(18),13,15-hexaene-7,15-dicarboxylic acid diethyl ester (223450-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 72 h

2: 60 percent / K₂CO₃ / dimethylformamide / 72 h / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1055/s-1999-3385

upstream raw materials:

3,5-bis[bromomethyl]benzoic acid ethyl ester

3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester

benzyl N-(4-methylbenzenesulfonyl)carbamate

Downstream raw materials:

[15-Hydroxymethyl-3,11-bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaen-7-yl]-methanol

3,7,10-tris-(toluene-4-sulfonyl)-3,7,10-triaza-1,5(1,3,5)-dibenzena-bicyclo[3.3.3]undecaphane

[15-Mercaptomethyl-3,11-bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaen-7-yl]-methanethiol

7,15-Bis-bromomethyl-3,11-bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene