(1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

Base Information

Chemical Name:(1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine
CAS No.:156126-14-6
Molecular Formula:C₁₇H₂₃NO₃
Molecular Weight:289.375
Hs Code.:

Synonyms:(1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

Suppliers and Price of (1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

There total 5 articles about (1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (1aR,1bR,4aS,5R,5aS)-5-Azido-1a-benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalene

: 156126-14-6
(1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

Guidance literature:: With hydrogen; Lindlar's catalyst; In methanol; ethyl acetate; for 3h;
DOI:10.1021/jm980111x

Reference yield:

: 89291-76-9
(1S,4R,5S)-(-)-3-<(benzyloxy)methyl>-4,5-O-isopropylidene-2-cyclopenten-1-ol

: 156126-14-6
(1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / Et₂Zn / CH₂Cl₂; hexane / 15 h / Ambient temperature

2: pyridine / 2 h / 0 °C

3: NaN₃ / dimethylformamide / 18 h / 100 °C

4: 100 percent / H₂ / Lindlar's catalyst / methanol; ethyl acetate / 3 h

With pyridine; sodium azide; hydrogen; diethylzinc; Lindlar's catalyst; In methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm980111x

Reference yield:

: 156126-13-5
(1aR,1bR,4aS,5S,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ol

: 156126-14-6
(1aR,1bR,4aS,5R,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 0 °C

2: NaN₃ / dimethylformamide / 18 h / 100 °C

3: 100 percent / H₂ / Lindlar's catalyst / methanol; ethyl acetate / 3 h

With pyridine; sodium azide; hydrogen; Lindlar's catalyst; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm980111x