Fmoc-Asp-OFm

Base Information

• Chemical Name: Fmoc-Asp-OFm
• CAS No.: 187671-16-5
• Molecular Formula: C₃₃H₂₇NO₆
• Molecular Weight: 533.58
• Mol file: 187671-16-5.mol

Synonyms:Fmoc-Asp-OFm;

Chemical Property of Fmoc-Asp-OFm

Chemical Property:

• Refractive Index: 1.647
• Boiling Point: 777.9 °C at 760 mmHg
• Flash Point: 424.3 °C
• PSA: 101.93000
• Density: 1.322 g/cm³
• LogP: 6.11500
• Storage Temp.: Store at 0°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-asp-ofm ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Fmoc-Asp-OFm

There total 2 articles about Fmoc-Asp-OFm which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Asp(OtBu)-OFm → Fmoc-Asp-OFm (187671-16-5)

Guidance literature:

With trifluoroacetic acid; In water; at 20 ℃; for 3h;

Reference yield:

9-Fluorenylmethanol (24324-17-2) + Fmoc-(tBu)Asp-OH (71989-14-5) → Fmoc-Asp-OFm (187671-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 7.5 h / 0 - 20 °C

2: trifluoroacetic acid / water / 3 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water;

Reference yield: 81.2%

Fmoc-(tBu)Asp-OH (71989-14-5) + Fmoc-Asp-OFm (187671-16-5) → (3S,6S)-2,5-dioxopiperazine-3,6-diacetic acid (35309-53-6)

Guidance literature:

Fmoc-Asp-OFm; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; 2-CTC Resin Inert atmosphere;

With piperidine; In N,N-dimethyl-formamide; for 0.25h; 2-CTC Resin

Fmoc-(tBu)Asp-OH; Further stages;

upstream raw materials:

9-Fluorenylmethanol

Fmoc-(tBu)Asp-OH

Downstream raw materials:

(3S,6S)-2,5-dioxopiperazine-3,6-diacetic acid

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