2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid

Base Information

• Chemical Name: 2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid
• CAS No.: 1377451-41-6
• Molecular Formula: C₁₇H₁₇NO₄
• Molecular Weight: 299.326
• Mol file: 1377451-41-6.mol

Synonyms:2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid

Chemical Property of 2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid

Chemical Property:

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Technology Process of 2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid

There total 3 articles about 2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

sodium [(1,3-dioxoisoindolin-2-yl)methyl]trifluoroborate + 4-bromo-3-methylanisole (27060-75-9) → 2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid (1377451-41-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; water; for 36h; Reflux;

DOI:10.1021/ol301037s

Reference yield: 85.1%

sodium [(1,3-dioxoisoindolin-2-yl)methyl]trifluoroborate + 1-chloro-4-methoxy-2-methylbenzene (13334-71-9) → 2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid (1377451-41-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate; In 1,4-dioxane; water; for 36h; Reflux;

DOI:10.1021/ol301037s

Reference yield:

sodium [(1,3-dioxoisoindolin-2-yl)methyl]trifluoroborate + 4-bromo-3-methylanisole (27060-75-9) → N-(4-methoxy-2-methylbenzyl)phthalimide (84888-48-2) + 2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid (1377451-41-6) + 1-methoxy-3-methyl-benzene (100-84-5)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; for 36h; Reflux;

DOI:10.1021/ol301037s

upstream raw materials:

4-bromo-3-methylanisole

1-chloro-4-methoxy-2-methylbenzene

Downstream raw materials:

(4-methoxy-2-methylphenyl)methanamine