4-METHOXY-2-METHYLBENZYLAMINE Hydrochloride

Base Information

• Chemical Name: 4-METHOXY-2-METHYLBENZYLAMINE Hydrochloride
• CAS No.: 21883-14-7
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Mol file: 21883-14-7.mol

Synonyms:4-Methoxy-2-methyl-benzylamin;4-methoxy-2-methyl-benzylamine;

Chemical Property of 4-METHOXY-2-METHYLBENZYLAMINE Hydrochloride

Chemical Property:

• PSA: 35.25000
• LogP: 2.16260

Purity/Quality:

99% ^*data from raw suppliers

(4-methoxy-2-methylphenyl)methanamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-2-METHYLBENZYLAMINE Hydrochloride

There total 6 articles about 4-METHOXY-2-METHYLBENZYLAMINE Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-3-methylanisole (27060-75-9) → (4-methoxy-2-methylphenyl)methanamine (21883-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate / 1,4-dioxane; water / 36 h / Reflux

2: ethylenediamine / 1,4-dioxane; propan-1-ol; water / 24 h / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; ethylenediamine; In 1,4-dioxane; propan-1-ol; water; 1: Suzuki-miyaura coupling;

DOI:10.1021/ol301037s

Reference yield:

4-methoxy-2-methylbenzonitrile (21883-13-6) → (4-methoxy-2-methylphenyl)methanamine (21883-14-7)

Guidance literature:

With lithium aluminium tetrahydride; In 1,2-dimethoxyethane;

DOI:10.1021/jm9000242

Reference yield:

1-chloro-4-methoxy-2-methylbenzene (13334-71-9) → (4-methoxy-2-methylphenyl)methanamine (21883-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate / 1,4-dioxane; water / 36 h / Reflux

2: ethylenediamine / 1,4-dioxane; propan-1-ol; water / 24 h / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate; ethylenediamine; In 1,4-dioxane; propan-1-ol; water; 1: Suzuki-miyaura coupling;

DOI:10.1021/ol301037s

upstream raw materials:

4-methoxysalicylaldehyde

4-methoxy-2-methylbenzonitrile

2-{[(4-methoxy-2-methylphenyl)methyl]carbamoyl}benzoic acid

4-bromo-3-methylanisole

Downstream raw materials:

4-Methoxy-2-methyl-benzyldimethylamin-methoiodid