2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid

Base Information

Chemical Name:2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid
CAS No.:1566585-21-4
Molecular Formula:C₃₂H₃₄F₆N₄O₄
Molecular Weight:652.637
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid

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Chemical Property of 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid

There total 9 articles about 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1566585-20-3
tert-butyl 4-(4-((4-(2-(2-methoxy-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

: 1566585-21-4
2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

Reference yield:

: 732306-26-2
2-(2-bromo-5-(trifluoromethyl)phenyl)acetonitrile

: 1566585-21-4
2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / water / 336 h / Reflux

2: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C

4: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 24 h / 2585.81 Torr

6: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; sulfuric acid; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1566585-18-9
methyl 2-(2-ethynyl-5-(trifluoromethyl)phenyl)acetate

: 1566585-21-4
2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 24 h / 2585.81 Torr

3: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;