2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide

Base Information

• Chemical Name: 2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide
• CAS No.: 1566584-07-3
• Molecular Formula: C₂₇H₂₇F₆N₅O
• Molecular Weight: 551.535
• Mol file: 1566584-07-3.mol

Synonyms:2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide

Chemical Property of 2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide

There total 11 articles about 2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1566585-22-5) → 2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide (1566584-07-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

methyl 2-(5-(trifluoromethyl)-2-((trimethylsilyl)ethynyl)phenyl)acetate (1566585-17-8) → 2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide (1566584-07-3)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C

2: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 24 h / 2585.81 Torr

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 72 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With ammonium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid (1566585-21-4) → 2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide (1566584-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 72 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With ammonium carbonate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-(2-bromo-5-(trifluoromethyl)phenyl)acetonitrile

methyl 2-(2-bromo-5-(trifluoromethyl)phenyl)acetate

methyl 2-(5-(trifluoromethyl)-2-((trimethylsilyl)ethynyl)phenyl)acetate

methyl 2-(2-ethynyl-5-(trifluoromethyl)phenyl)acetate