tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
• CAS No.: 1566585-22-5
• Molecular Formula: C₃₂H₃₅F₆N₅O₃
• Molecular Weight: 651.652
• Mol file: 1566585-22-5.mol

Synonyms:tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetic acid (1566585-21-4) → tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1566585-22-5)

Guidance literature:

With ammonium carbonate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

2-(2-bromo-5-(trifluoromethyl)phenyl)acetonitrile (732306-26-2) → tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1566585-22-5)

Guidance literature:

Multi-step reaction with 7 steps

1: sulfuric acid / water / 336 h / Reflux

2: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C

4: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 24 h / 2585.81 Torr

6: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 72 h / 20 °C

With ammonium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; sulfuric acid; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

methyl 2-(2-ethynyl-5-(trifluoromethyl)phenyl)acetate (1566585-18-9) → tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-4-(trifluoromethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1566585-22-5)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 24 h / 2585.81 Torr

3: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 72 h / 20 °C

With ammonium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-(2-bromo-5-(trifluoromethyl)phenyl)acetonitrile

methyl 2-(2-bromo-5-(trifluoromethyl)phenyl)acetate

methyl 2-(5-(trifluoromethyl)-2-((trimethylsilyl)ethynyl)phenyl)acetate

methyl 2-(2-ethynyl-5-(trifluoromethyl)phenyl)acetate

Downstream raw materials:

2-(2-(2-(2-((4-(piperidine-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-5-(trifluoromethyl)phenyl)acetamide