3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide

Base Information

• Chemical Name: 3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide
• CAS No.: 650625-30-2
• Molecular Formula: C₂₃H₃₀N₂O₃
• Molecular Weight: 382.503

Synonyms:3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide

Chemical Property of 3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide

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Technology Process of 3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide

There total 4 articles about 3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-(benzyloxy)-2,2-dimethylpropionic acid (36881-14-8) + 2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine (75755-40-7) → 3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide (650625-30-2)

Guidance literature:

In tetrahydrofuran; for 24h;

DOI:10.1002/hlca.200390262

Reference yield:

Methyl 2,2-dimethyl-3-hydroxypropionate (14002-80-3) → 3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide (650625-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / NaH / tetrahydrofuran / 3 h / Heating

2: 88 percent / aq. KOH / ethanol / 1 h / 20 °C

3: 84 percent / tetrahydrofuran / 24 h

With potassium hydroxide; sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1002/hlca.200390262

Reference yield:

benzyl bromide (100-39-0) → 3-benzyloxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide (650625-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / NaH / tetrahydrofuran / 3 h / Heating

2: 88 percent / aq. KOH / ethanol / 1 h / 20 °C

3: 84 percent / tetrahydrofuran / 24 h

With potassium hydroxide; sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1002/hlca.200390262

upstream raw materials:

3-(benzyloxy)-2,2-dimethylpropionic acid

2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

Methyl 2,2-dimethyl-3-hydroxypropionate

benzyl bromide

Downstream raw materials:

2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-benzyloxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

2-[(3-benzyloxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoic acid

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