ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

Base Information

Chemical Name:ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate
CAS No.:124177-09-9
Molecular Formula:C₁₃H₂₂O₃
Molecular Weight:226.316
Hs Code.:

Synonyms:ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

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Chemical Property of ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

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Technology Process of ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

There total 7 articles about ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 124177-08-8,124263-01-0
ethyl (1R,3S)-3-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6-methylenecyclohexaneacetate

: 124177-09-9
ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

: 124263-02-1
ethyl (1S,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

Guidance literature:: With hydrogen fluoride; In acetonitrile; for 4h; Ambient temperature;

Reference yield:

: 124177-06-6
(S)-4-(tert-butyldimethylsilyloxy)-3,3-dimethyl-1-cyclohexenecarbaldehyde

: 124177-09-9
ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaBH₄ / aq. ethanol; tetrahydrofuran / 1 h / 0 - 5 °C

2: 85 percent / propionic acid / 2 h / 130 - 140 °C

3: 21 percent / 46percent hydrofluoric acid / acetonitrile / 4 h / Ambient temperature

With sodium tetrahydroborate; hydrogen fluoride; propionic acid; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 106540-31-2
(+)-(S)-3-(tert-butyldimethylsiloxy)-2,2-dimethylcyclohexanone

: 124177-09-9
ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) sodium hydride / 1.) THF, benzene, 10 min 2.) ca. 12 h, room temperature

2: p-toluenesulfonic acid / benzene / 2 h / Heating

3: NaBH₄ / aq. ethanol; tetrahydrofuran / 1.5 h / 0 - 4 °C

4: cadmium carbonate, mercuric chloride / aq. ethanol / 0.05 h / Heating

5: 100 percent / NaBH₄ / aq. ethanol; tetrahydrofuran / 1 h / 0 - 5 °C

6: 85 percent / propionic acid / 2 h / 130 - 140 °C

7: 21 percent / 46percent hydrofluoric acid / acetonitrile / 4 h / Ambient temperature

With sodium tetrahydroborate; cadmium(II) carbonate; hydrogen fluoride; sodium hydride; toluene-4-sulfonic acid; propionic acid; mercury dichloride; In tetrahydrofuran; ethanol; acetonitrile; benzene;