3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one

Base Information

Chemical Name:3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one
CAS No.:1588422-93-8
Molecular Formula:C₂₇H₃₀ClN₅O₃
Molecular Weight:508.02
Hs Code.:

Synonyms:3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one

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Chemical Property of 3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one

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Technology Process of 3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one

There total 15 articles about 3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1250588-98-7
5-(2-diethylaminoethoxy)pyridin-2-ylamine

: 1588424-12-7
C₁₆H₁₂Cl₂N₂O₂

: 1588422-93-8
3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; XPhos; In 1,4-dioxane; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1588422-93-8
3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 16.5 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

3.1: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

5.1: acetic anhydride / 2 h / 120 °C

5.2: 8 h / 90 °C

6.1: boron tribromide / dichloromethane / 1 h / 0 °C

7.1: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; acetic anhydride; boron tribromide; potassium carbonate; Dess-Martin periodane; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1588422-93-8
3-(2-chloro-6-hydroxyphenyl)-7-((5-(2-(diethylamino)ethoxy)pyridin-2-yl)amino)-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

2.1: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

4.1: acetic anhydride / 2 h / 120 °C

4.2: 8 h / 90 °C

5.1: boron tribromide / dichloromethane / 1 h / 0 °C

6.1: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; acetic anhydride; boron tribromide; potassium carbonate; Dess-Martin periodane; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;