N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

Base Information

• Chemical Name: N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine
• CAS No.: 1357101-76-8
• Molecular Formula: C₂₂H₂₃N₅O₃
• Molecular Weight: 405.456

Synonyms:N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

Chemical Property of N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

There total 11 articles about N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + N2-(3,5-dimethyl-4-hydroxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1357101-75-7) → N2-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1357101-76-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

tert-butyl 4-amino-2,6-dimethylbenzoate (306296-73-1) → N2-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1357101-76-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / isopropyl alcohol / 100 °C / Sealed tube

2.1: hydrogenchloride / 1,4-dioxane; methanol / 8 h / 40 - 50 °C

2.2: pH 3

3.1: borane-THF / tetrahydrofuran / 0 - 20 °C

3.2: pH 7

4.1: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; borane-THF; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; isopropyl alcohol;

Reference yield:

N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide (306297-11-0) → N2-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1357101-76-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: methyllithium / diethyl ether; tetrahydrofuran / -78 °C

1.2: 0.08 h / -78 °C

1.3: 3.5 h / -78 - 20 °C

2.1: sodium hydroxide; water / methanol / 20 - 60 °C

3.1: trifluoroacetic acid / isopropyl alcohol / 100 °C / Sealed tube

4.1: hydrogenchloride / 1,4-dioxane; methanol / 8 h / 40 - 50 °C

4.2: pH 3

5.1: borane-THF / tetrahydrofuran / 0 - 20 °C

5.2: pH 7

6.1: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; borane-THF; water; methyllithium; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; isopropyl alcohol;

upstream raw materials:

5-amino-2-benzoxazolinone

3,5-dimethylaminoaniline

N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide

N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1357101-76-8 N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send