5-PHENYLPYRROLE-2-CARBOXALDEHYDE

Base Information

• Chemical Name: 5-PHENYLPYRROLE-2-CARBOXALDEHYDE
• CAS No.: 52179-74-5
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Hs Code.: 2933990090
• Mol file: 52179-74-5.mol

Synonyms:2-Formyl-5-phenyl-pyrrole;

Chemical Property of 5-PHENYLPYRROLE-2-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 1.3E-05mmHg at 25°C
• Melting Point: 137-138 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Refractive Index: 1.638
• Boiling Point: 368.1 °C at 760 mmHg
• PKA: 15.16±0.50(Predicted)
• Flash Point: 184 °C
• PSA: 32.86000
• Density: 1.183 g/cm³
• LogP: 2.49420

Purity/Quality:

98%min ^*data from raw suppliers

5-PHENYLPYRROLE-2-CARBOXALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PHENYLPYRROLE-2-CARBOXALDEHYDE

There total 20 articles about 5-PHENYLPYRROLE-2-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-phenyl-1H-pyrrole (3042-22-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-phenyl-1H-pyrrole-2-carbaldehyde (52179-74-5)

Guidance literature:

2-phenyl-1H-pyrrole; N,N-dimethyl-formamide; With trichlorophosphate; In toluene; at 20 ℃; Cooling with ice; Inert atmosphere;

With water; sodium hydrogencarbonate; sodium hydroxide; In toluene; at 0 ℃; for 3h; pH=7 - 12; Inert atmosphere;

DOI:10.1039/c5ce00927h

Reference yield: 82.0%

C12H9NO2 → 5-phenyl-1H-pyrrole-2-carbaldehyde (52179-74-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 70 ℃; for 14h;

DOI:10.1021/ol070340q

Reference yield: 80.0%

3-(oxazol-4-yl)-1-phenylprop-2-en-1-one → 5-phenyl-1H-pyrrole-2-carbaldehyde (52179-74-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 70 ℃; for 14h;

upstream raw materials:

2-phenyl-1H-pyrrole

chloroform

N-(hydroxy-2' ethyl) amino-3 phenyl-3 propenoate d'ethyle

hydrogenchloride

Downstream raw materials:

N-[(5-phenyl-1H-pyrrol-2-yl)methylene]benzene-1,2-diamine

1-phenylpyrrolo[1,2-a]quinoxaline

2-cyclohexylmethyl-5-phenylpyrrole

(+)-(R)-5-pentyl-2-phenyl-1-pyrroline