(S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate

Base Information

Chemical Name:(S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate
CAS No.:1284303-90-7
Molecular Formula:C₂HF₃O₂*C₁₈H₂₁F₂NO
Molecular Weight:419.392
Hs Code.:

Synonyms:(S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate

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Technology Process of (S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate

There total 2 articles about (S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1284303-74-7
(S)-2-amino-1,1-bis(4-fluorophenyl)-3,3-dimethylbutan-1-ol

: 76-05-1
trifluoroacetic acid

: 1284303-90-7
(S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate

Guidance literature:: In dichloromethane; at 0 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1021/jo501433c

Reference yield:

: 63038-27-7,167223-43-0
L-tert-leucine methyl ester hydrochloride

: 352-13-6
4-flourophenylmagnesium bromide

: 1284303-90-7
(S)-1,1-bis(4-fluorophenyl)-1-hydroxy-3,3-dimethylbutan-2-aminium trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 24.5 h / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 0.08 h / 0 °C / Inert atmosphere

In diethyl ether; dichloromethane; 1: |Grignard Reaction;
DOI:10.1021/jo501433c