89-20-3

Basic information

• Product Name: 4-Chlorophthalic acid
• Synonyms: 4-CHLOROPHTHALIC ACID;P-CHLOROPHTHALIC ACID;4-Chloro-1,2-benzenedicarboxylic acid;4-chloro-o-phthalic acid;1,2-Benzenedicarboxylic acid, 4-chloro-
• CAS NO: 89-20-3
• Molecular Formula: C₈H₅ClO₄
• Molecular Weight: 200.58
• EINECS: 201-886-3
• Product Categories: pharmacetical
• Mol File: 89-20-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 157 °C
• Boiling Point: 399.5 °C at 760 mmHg
• Flash Point: 195.4 °C
• Appearance: /
• Density: 1.586 g/cm³
• Vapor Pressure: 4.22E-07mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.88±0.10(Predicted)
• CAS DataBase Reference: 4-Chlorophthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorophthalic acid(89-20-3)
• EPA Substance Registry System: 4-Chlorophthalic acid(89-20-3)

Safety Data

• Hazardous Substances Data: 89-20-3(Hazardous Substances Data)

Usage

General Description

4-Chlorophthalic acid, also known as para-chlorophthalic acid or 4-CPA, is a type of aromatic organic compound that features a phthalic acid core with a chlorine atom attached. This off-white crystalline solid is commonly synthesized using a Friedel-Crafts reaction, using chlorine and phthalic acid or phthalic anhydride as the primary reactants. It is chiefly applied in the preparation of dyes for pharmaceuticals and textiles, as well as in the development of certain types of polymers. Despite this, it is highly hazardous upon ingestion or inhalation and could lead to severe eye and skin irritation.

InChI:InChI=1/C8H5ClO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 56-23-5 tetrachloromethane 
• 610-27-5 4-nitrophthalic acid 
• 2198-77-8 2,7-dichloronaphthalene 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 58231-16-6 4-chloro-2-ethylbenzoic acid 
• 24127-36-4 2-chloro-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-one 
• 50-84-0 2,4 dichlorobenzoic acid 
• 201230-82-2 carbon monoxide 
• 7782-50-5 chlorine 
• 2065-70-5 2,6-dichloronaphthalene 
• 7697-37-2 nitric acid 
• 56961-92-3 6-chloro-1,4-naphthoquinone 
• 29016-72-6 1-bromo-7-chloronaphthalene 
• 64-19-7 acetic acid 

Downstream Products

• 58138-38-8 dimethyl 4-chlorophthalate 
• 38717-95-2 4-chlorodiethylphthalate 
• 118-45-6 4-chlorophthalic anhydride 
• 110706-49-5 4-chloro-2-(hydroxymethyl)benzyl alcohol 
• 610-35-5 4-hydroxyphthalic acid 
• 1220-95-7 6-chloroquinizarin 
• 876291-65-5 (5-chloro-1,3-dioxo-2-phenyl-indan-2-yl)-acetaldehyde 
• 876291-61-1 2-allyl-5-chloro-2-phenyl-indan-1,3-dione 
• 1470-36-6 5-chloro-2-phenylindan-1,3-dione 
• 38103-06-9 4,4'-bis(4,4'-isopropylidene diphenoxy)-bis(phthalic anhydride) 
• 17828-53-4 1,4-bis(3,4-dicarboxyphenoxy)benzene dianhydride 
• 872181-41-4 2-(5-chloro-2-methoxymethoxymethylbenzyloxy)-6-fluorobenzonitrile 
• 872181-40-3 (5-chloro-2-methoxymethoxymethylphenyl)methanol 

Relevant articles and documents

-

-

Preparation method for biphenyltetracarboxylic dianhydride mixture

The invention relates to a preparation method for a biphenyltetracarboxylic dianhydride mixture. The preparation method comprises the following steps: with phthalic acid as a starting raw material, carrying out an electrophilic substitution reaction so as to produce a phthalic acid derivative; then subjecting the derivative to esterification so as to produce phthalate; further catalyzing phthalate and carrying out a coupling reaction so as to produce a biphenyl tetraformate mixture; and finally, successively carrying out saponification and acidification so as to produce the product biphenyltetracarboxylic dianhydride mixture. The method provided by the invention uses cheap and easily phthalic acid as the starting raw material and is a novel low-cost easily-operatable environment-friendly production method for biphenyltetracarboxylic dianhydride; moreover, isomeric compounds of all the biphenyltetracarboxylic dianhydride are synthesized at one time in the invention, so efficiency is improved and the cost is reduced.

METHOD OF PURIFYING DIANHYDRIDES, THE DIANHYDRIDES FORMED THEREBY, AND POLYETHERIMIDES FORMED THEREFROM

A method for purifying an oxydiphthalic anhydride comprises diluting a first mixture comprising an oxydiphthalic anhydride, a solvent, a catalyst, and an inorganic salt with a solvent, to provide a second mixture having a solids content of 10 to 30 percent based on total weight of the second mixture; filtering and washing the solids of the second mixture at a temperature below the crystallization point temperature of the oxydiphthalic anhydride to provide a third mixture; hydrolyzing the third mixture by adding water and a water-soluble acid to form a fourth mixture; heating the fourth mixture; then cooling to provide a solid-liquid mixture, optionally decanting a portion of the liquid, re diluting the remaining solid-liquid mixture, then filtering to provide a solid component; washing the solid component with water to provide a fifth mixture of oxydiphthalic tetra acid and water; ring closing the oxydiphthalic tetra acid to provide oxydiphthalic anhydride, and filtering the oxydiphthalic anhydride.

2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY

2,4-Diaminoquinazolines of formulae I-IV and VI (I, II, III, IV and VI) are useful for treating spinal muscular atrophy (SMA).