C₄₃H₅₂N₈O₆S

Base Information

• Chemical Name: C₄₃H₅₂N₈O₆S
• CAS No.: 1312608-59-5
• Molecular Formula: C₄₃H₅₂N₈O₆S
• Molecular Weight: 809.002

Synonyms:C₄₃H₅₂N₈O₆S

Chemical Property of C₄₃H₅₂N₈O₆S

Chemical Property:

Purity/Quality:

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Technology Process of C₄₃H₅₂N₈O₆S

There total 15 articles about C₄₃H₅₂N₈O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

2C2HF3O2*C29H30N6S + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → C43H52N8O6S (1312608-59-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → C43H52N8O6S (1312608-59-5)

Guidance literature:

Multi-step reaction with 15 steps

1.1: potassium hydroxide / water; tetrahydrofuran / 0 - 20 °C

2.1: diphenylether / 240 - 250 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 2 h / Inert atmosphere; Reflux

4.1: sodium hydroxide / water / 4 h / 100 °C

4.2: 20 °C / pH 4 - 5

5.1: sodium hydroxide / diphenylether; water / 6 h / 100 °C

5.2: 20 °C / pH 4 - 5

6.1: copper; quinoline / 1.5 h / 210 - 220 °C / Inert atmosphere

7.1: bromine / tetrachloromethane / 2.5 h / 0 °C

8.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 80 °C / Inert atmosphere

9.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

9.2: 1 h

10.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

10.2: Cooling with ice

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

12.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

13.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

14.1: dichloromethane / 1 h / 20 °C

15.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

With quinoline; n-butyllithium; water; bromine; potassium acetate; boron tribromide; copper; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; hexanes; diphenylether; dichloromethane; water; 8.1: Suzuki Coupling / 13.1: Suzuki Coupling;

Reference yield:

7-methoxybenzothiophene (88791-08-6) → C43H52N8O6S (1312608-59-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: bromine / tetrachloromethane / 2.5 h / 0 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 80 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

3.2: 1 h

4.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

4.2: Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

7.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

8.1: dichloromethane / 1 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

With n-butyllithium; bromine; potassium acetate; boron tribromide; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; hexanes; dichloromethane; water; 2.1: Suzuki Coupling / 7.1: Suzuki Coupling;

upstream raw materials:

N-methoxycarbonyl-L-valine

3-methoxy-2-hydroxybenzaldehyde

7-methoxybenzothiophene

O-(2-formyl-6-methoxyphenyl)-N,N-dimethylthiocarbamate

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