88791-08-6

Basic information

• Product Name: 7-METHOXY-BENZO[B]THIOPHENE
• Synonyms: 7-METHOXY-BENZO[B]THIOPHENE;7-METHOXY-1-BENZOTHIOPHENE;7-Methoxybenzothiophene
• CAS NO: 88791-08-6
• Molecular Formula: C₉H₈OS
• Molecular Weight: 164.22422
• Mol File: 88791-08-6.mol

Chemical Properties

• Boiling Point: 140-145 °C(Press: 15 Torr)
• Appearance: /
• Density: 1.198±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-METHOXY-BENZO[B]THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-BENZO[B]THIOPHENE(88791-08-6)
• EPA Substance Registry System: 7-METHOXY-BENZO[B]THIOPHENE(88791-08-6)

Safety Data

• Hazardous Substances Data: 88791-08-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Methoxy-benzo[b]thiophene is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with unique therapeutic properties. Its incorporation into drug molecules can enhance their efficacy, selectivity, and pharmacokinetic profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 7-Methoxy-benzo[b]thiophene is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties allow for the creation of compounds that can effectively control pests and weeds, thereby improving crop yields and quality.
Used in Material Science:
7-Methoxy-benzo[b]thiophene is employed as a component in the development of advanced materials with specific properties, such as conductivity, stability, or optical characteristics. Its unique structure enables the creation of materials with tailored properties for use in various applications, including electronics, sensors, and energy storage devices.
Used in Chemical Research and Development:
As a versatile chemical intermediate, 7-Methoxy-benzo[b]thiophene is used in research and development for exploring new chemical reactions, synthesis pathways, and the creation of novel organic compounds. Its reactivity and structural features make it a valuable tool for advancing the understanding of chemical processes and the discovery of new chemical entities.

Upstream product

• 7217-59-6 2-Methoxybenzenethiol 
• 62924-93-0 N,N-diethyl-3-methoxybenzamide 
• 51830-50-3 1,1-diethoxy-2-(4-methylphenylthio)ethane 
• 88791-06-4 (2-formyl-6-methoxyphenylthio)acetic acid 
• 88791-05-3 2-mercapto-3-methoxybenzaldehyde 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 72002-20-1 2,3-dihydro-7-methoxybenzo[b]thiophen-3-one 
• 96803-64-4 2-(2-methoxythiophenoxy)acetaldehyde diethyl acetal 
• 77898-35-2 7-hydroxybenzo[b]thiophene 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 180895-61-8 4-di(2-thienyl)-1,4-butanedione 
• 103181-65-3 (2-methoxy-phenylsulfanyl)-acetaldehyde dimethylacetal 
• 88791-04-2 S-(2-formyl-6-methoxyphenyl)-N,N-dimethylthiocarbamate 

Downstream Products

• 88791-18-8 7-methoxybenzothiophene-2-carbonitrile 
• 193965-35-4 (7-methoxy-1-benzothiophen-2-yl)boronic acid 
• 1312608-59-5 C₄₃H₅₂N₈O₆S 
• 1312610-32-4 C₃₉H₄₆N₆O₄S 
• 1312610-31-3 C₂₇H₃₄B₂O₄S 
• 1312610-30-2 C₁₇H₁₀F₆O₆S₃ 
• 1312610-29-9 C₁₅H₁₂O₂S 
• 1312610-28-8 C₁₇H₁₆O₂S 
• 1312608-58-4 C₄₂H₅₀N₈O₆S 
• 1312610-06-2 C₂₈H₂₈N₆S 
• 1312610-05-1 C₃₈H₄₄N₆O₄S 
• 1312610-04-0 C₂₆H₃₂B₂O₄S 
• 1312610-03-9 C₁₆H₈F₆O₆S₃ 
• 1312610-02-8 C₁₄H₁₀O₂S 

Relevant articles and documents

Compound with AMPK agonistic activity and preparation and application of prodrug thereof

The invention relates to a compound with AMPK agonistic activity and a prodrug thereof, and as well as a preparation method and medical application of a prodrug thereof. The compound has the structure shown in the formula (I), and the prodrug of the compound has the structure shown in the formula (II), wherein each group and the substituent are as defined in the specification. The invention discloses a preparation method of the compound and application of the compound in prevention and treatment AMPK related diseases, and the AMPK related diseases include, but are not limited to, energy metabolism abnormality related diseases. Neurodegenerative diseases and inflammation-related diseases and the like.

NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

3-ARYLOXY/ THIO-2, 3-SUBSTITUTED PROPANAMINES AND THEIR USE IN INHIBITING SEROTONIN AND NOREPINEPHRINE REUPTAKE

There is provided a compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4 alkyl, and C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, -CF3, -CN and -CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4 alkyl; Z is selected from OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereofwith the proviso that when Y is optionally substituted phenyl or optionally substituted 1,3-benzodioxolyl and Z is OR3 and X is optionally substituted phenyl then A is -S-.

Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake

A series of benzothienyloxy phenylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.

Application of directed metalation in synthesis. Part 4: Expedient synthesis of substituted benzo[b]thiophene and naphthothiophene

A short, simple and inexpensive synthesis of several diversely substituted benzo[b]thiophenes and one naphthothiophene is described. The method involves introduction of methylsulfanyl group ortho- to the amide function of readily available N,N-diethylamides of aryl carboxylic acid by directed metalation. Thioindoxyls, obtained in high yields through side-chain deprotonation and cyclisation in one pot, are reduced to benzo[b]thiophene or napthothiophene.

Application of directed metallation in synthesis, part 2: An expedient synthesis of methoxybenzo[b]thiophenes

A short, simple and expedient synthesis of substituted benzo[b]thiophenes involving directed ortho lithiation-side-chain deprotonation-cyclisation-reduction is described. This method is a valuable improvement over earlier syntheses of the same class of compounds, both with respect to the number of steps and overall yields.

Antithrombotic diamines

This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[b]thiophenes

A novel series of benzo[b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain 3 was investigated. The constrained C3-side chain by a cyclohexyl ring contributed to not only an additive but also a synergistic effect on the thrombin inhibitory activity. The SAR studies resulted in the discovery of a potent thrombin inhibitor 27 that was over 750-fold more potent than the initial lead compound 1.