2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

Base Information

Chemical Name:2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid
CAS No.:1073119-63-7
Molecular Formula:C₁₅H₁₀Cl₂N₂O₃
Molecular Weight:337.162
Hs Code.:

Synonyms:2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

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Technology Process of 2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

There total 1 articles about 2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1009080-15-2
2-(6,8-dichloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

: 1073119-63-7
2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

Guidance literature:: With hydrogen bromide; In water; for 4h; Reflux; Inert atmosphere;
DOI:10.1021/jm8006728

Reference yield: 45.0%

: 110-68-9
N-n-butyl-N-methylamine

: 1073119-63-7
2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

: 1073119-13-7
2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N-butyl-N-methylacetamide

Guidance literature:: 2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

N-n-butyl-N-methylamine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm8006728

Reference yield: 43.0%

: 1073119-63-7
2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

: 142-84-7
di-n-propylamine

: 1073119-12-6
N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

Guidance literature:: 2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

di-n-propylamine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm8006728