N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

Base Information

• Chemical Name: N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide
• CAS No.: 1073119-12-6
• Molecular Formula: C₂₁H₂₃Cl₂N₃O₂
• Molecular Weight: 420.339

Synonyms:N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

Chemical Property of N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

Chemical Property:

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Technology Process of N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

There total 2 articles about N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid (1073119-63-7) + di-n-propylamine (142-84-7) → N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide (1073119-12-6)

Guidance literature:

2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

di-n-propylamine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm8006728

Reference yield:

ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate (1402402-87-2) → N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide (1073119-12-6)

Guidance literature:

With methanol; In aq. phosphate buffer; at 37 ℃; pH=7.4;

DOI:10.1016/j.ijpharm.2012.08.023

Reference yield: 95.0%

N,N-di-n-propyl-[2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide (1073119-12-6) + succinic acid monomethylester chloride (1490-25-1) → 4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl methyl succinate (1073119-17-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm8006728

upstream raw materials:

2-(6,8-dichloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

di-n-propylamine

ethyl-2-((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridine-2-yl)phenoxy)carbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

Downstream raw materials:

4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 2-(tert-butoxycarbonylamino)acetate

4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl methyl succinate

4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-ylcarbamate

4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

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