120690-70-2Relevant academic research and scientific papers
CHEMICAL COMPOUNDS
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Page/Page column 105, (2008/12/04)
Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
Total syntheses of 6- and 7-azaindole derived GnRH antagonists
Ujjainwalla, Feroze,Walsh, Thomas F.
, p. 6441 - 6445 (2007/10/03)
The palladium(0)-catalyzed heteroannulation of a triethylsilyl alkyne and an ortho-aminoiodopyridine derivative is used as the key step in a highly convergent route to 6- and 7-azaindoles of biological interest.
ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE
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, (2008/06/13)
There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
Antagonists of gonadotropin releasing hormone
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, (2008/06/13)
There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
Antagonists of gonadotropin releasing hormone
-
, (2008/06/13)
There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE
-
, (2008/06/13)
There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and wo
ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE
-
, (2008/06/13)
There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
1,3-dioxanes
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, (2008/06/13)
The invention concerns novel, pharmaceutically useful 1,3-dioxane alkanoic and alkenoic acid derivatives of the formula I in which the groups at positions 2, 4 and 5 of the 1,3-dioxane ring have cis-relative stereochemistry, Y is ethylene or vinylene, n is 1-4, Z is hydrogen or hydroxy, and X is a pyridine containing group (as defined hereinafter); and the pharmaceutically acceptable salts thereof. The invention also includes processes for the manufacture and use of the acid derivatives as well as pharmaceutical compositions for therapeutic use in one or more of a variety of diseases such as ischaemic heart disease, cerebrovascular disease, asthmatic disease and/or inflammatory disease.
