4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone

Base Information

Chemical Name:4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone
CAS No.:1363808-52-9
Molecular Formula:C₁₇H₂₂N₂OS
Molecular Weight:302.44
Hs Code.:

Synonyms:4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone

There total 13 articles about 4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363807-48-0
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-methylsulfanyl-2,3-dihydro-3-pyridazinone

: 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-2,3-dihydro-3-pyridazinone

: 1363808-52-9
4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone

Guidance literature:: 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-methylsulfanyl-2,3-dihydro-3-pyridazinone; With sodium methylate; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 16h;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 1363806-98-7
ethyl 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetate

: 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-2,3-dihydro-3-pyridazinone

: 1363808-52-9
4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere

3.1: triethylamine / toluene / 4 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 2.5 h / 0 °C / Inert atmosphere

5.1: sodium methylate / 1-methyl-pyrrolidin-2-one / 16 h / 90 °C

5.2: pH 1

With thionyl chloride; water; sodium methylate; sodium hydride; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;

Reference yield:

: 314084-61-2
1-bromo-2,6-diethyl-4-methylbenzene

: 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-2,3-dihydro-3-pyridazinone

: 1363808-52-9
4-(2,6-diethyl-4-methylphenyl)-5-mercapto-2,6-dimethyl-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium; ethylene dibromide / toluene; tetrahydrofuran / 52 h / 40 - 50 °C / Inert atmosphere

1.2: 2 h / 0 - 5 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere

4.1: triethylamine / toluene / 4 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran / 2.5 h / 0 °C / Inert atmosphere

6.1: sodium methylate / 1-methyl-pyrrolidin-2-one / 16 h / 90 °C

6.2: pH 1

With thionyl chloride; water; sodium methylate; sodium hydride; magnesium; ethylene dibromide; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;