benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Base Information

Chemical Name:benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide
CAS No.:1338820-99-7
Molecular Formula:C₂₂H₂₃FN₂O₄S
Molecular Weight:430.5
Hs Code.:

Synonyms:benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

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Chemical Property of benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

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Technology Process of benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

There total 9 articles about benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338820-98-6
C₂₃H₂₇FN₂O₇S₂

: 1338820-99-7
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 921599-74-8,852051-10-6
benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

: 1338820-99-7
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 18 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

3: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

4: hydrogenchloride; water / methanol / 0.5 h

5: sodium tetrahydroborate; methanol / 1 h / 20 °C

6: triethylamine / dichloromethane / 1 h / 0 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1193782-19-2
benzyl (2S,4R)-4-cyano-4-[(3-fluorophenyl)amino]-2-methyl-piperidine-1-carboxylate

: 1338820-99-7
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

2: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

3: hydrogenchloride; water / methanol / 0.5 h

4: sodium tetrahydroborate; methanol / 1 h / 20 °C

5: triethylamine / dichloromethane / 1 h / 0 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;