(5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide

Base Information

Chemical Name:(5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide
CAS No.:1338821-18-3
Molecular Formula:C₁₄H₁₉FN₂O₂S
Molecular Weight:298.381
Hs Code.:

Synonyms:(5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide

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Chemical Property of (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide

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Technology Process of (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide

There total 10 articles about (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1338820-99-7
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

: 1338821-18-3
(5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 22h; under 2585.81 Torr;

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1338821-18-3
(5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide

Guidance literature:: Multi-step reaction with 8 steps

1: acetic acid / 18 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

3: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

4: hydrogenchloride; water / methanol / 0.5 h

5: sodium tetrahydroborate; methanol / 1 h / 20 °C

6: triethylamine / dichloromethane / 1 h / 0 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

8: hydrogen; palladium 10% on activated carbon / ethanol / 22 h / 2585.81 Torr

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1193782-19-2
benzyl (2S,4R)-4-cyano-4-[(3-fluorophenyl)amino]-2-methyl-piperidine-1-carboxylate

: 1338821-18-3
(5R,7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,8-diazaspiro[4.5]decane 2,2-dioxide

Guidance literature:: Multi-step reaction with 7 steps

1: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

2: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

3: hydrogenchloride; water / methanol / 0.5 h

4: sodium tetrahydroborate; methanol / 1 h / 20 °C

5: triethylamine / dichloromethane / 1 h / 0 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

7: hydrogen; palladium 10% on activated carbon / ethanol / 22 h / 2585.81 Torr

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;