1,4-diacetylbenzene bis(trimethylsilyl) enol ether

Base Information

• Chemical Name: 1,4-diacetylbenzene bis(trimethylsilyl) enol ether
• CAS No.: 183060-22-2
• Molecular Formula: C₁₆H₂₆O₂Si₂
• Molecular Weight: 306.552
• Mol file: 183060-22-2.mol

Synonyms:1,4-diacetylbenzene bis(trimethylsilyl) enol ether

Chemical Property of 1,4-diacetylbenzene bis(trimethylsilyl) enol ether

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1,4-diacetylbenzene bis(trimethylsilyl) enol ether

There total 2 articles about 1,4-diacetylbenzene bis(trimethylsilyl) enol ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

trimethylsilyl trifluoromethanesulfonate (27607-77-8) + 1,4-Diacetylbenzene (1009-61-6) → 1,4-diacetylbenzene bis(trimethylsilyl) enol ether (183060-22-2)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1021/jm990363d

Reference yield:

chloro-trimethyl-silane (75-77-4) + 1,4-Diacetylbenzene (1009-61-6) → 1-[4-(1-Trimethylsilanyloxy-vinyl)-phenyl]-ethanone + 1,4-diacetylbenzene bis(trimethylsilyl) enol ether (183060-22-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield: 66.0%

1-phenylhept-2-ynyl acetate (111833-50-2) + 1,4-diacetylbenzene bis(trimethylsilyl) enol ether (183060-22-2) → 2-pentyl-5-(4-(5-pentyl-4-phenylfuran-2-yl)phenyl)-3-phenylfuran (1011517-64-8)

Guidance literature:

1-phenylhept-2-ynyl acetate; 1,4-diacetylbenzene bis(trimethylsilyl) enol ether; With copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 20 ℃; for 0.0833333h;

With toluene-4-sulfonic acid; In toluene; for 1h; Further stages.; Heating;

DOI:10.1002/adsc.200700234

upstream raw materials:

chloro-trimethyl-silane

1,4-Diacetylbenzene

trimethylsilyl trifluoromethanesulfonate

Downstream raw materials:

10-p-acetylphenylartemisinin dimer

2-pentyl-5-(4-(5-pentyl-4-phenylfuran-2-yl)phenyl)-3-phenylfuran