(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate

Base Information

Chemical Name:(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate
CAS No.:1417729-03-3
Molecular Formula:C₂₅H₂₄NO₅P
Molecular Weight:449.443
Hs Code.:

Synonyms:(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate

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Chemical Property of (6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate

Chemical Property:

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Technology Process of (6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate

There total 9 articles about (6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1417729-00-0
(4-bromo-6-[ethoxy(phenyl)phosphoryl]pyridine-2-yl)methyl acetate

: 768-60-5
4-methoxyphenylacetylen

: 1417729-03-3
(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; at 60 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c2cc35247h

Reference yield:

: 5315-25-3
2-bromo-6-methylpyridine

: 1417729-03-3
(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 65 °C / Inert atmosphere

2.1: nitric acid; sulfuric acid / 16 h / 0 - 100 °C

3.1: phosphorus tribromide / chloroform / 16 h / 60 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

5.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

5.2: 0 °C

6.1: 72 h / 140 °C / Inert atmosphere

7.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

8.1: 3 h / 120 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; sulfuric acid; nitric acid; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h

Reference yield:

: 97944-46-2
2-bromo-6-methyl-4-nitro-pyridine

: 1417729-03-3
(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

2.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

2.2: 0 °C

3.1: 72 h / 140 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

5.1: 3 h / 120 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h