2,3,4-Triphenylpyridine

Base Information

• Chemical Name: 2,3,4-Triphenylpyridine
• CAS No.: 130318-01-3
• Molecular Formula: C23H17N
• Molecular Weight: 307.395
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10534684
• Nikkaji Number: J1.685.211B
• Wikidata: Q82408627
• Mol file: 130318-01-3.mol

Synonyms:2,3,4-TRIPHENYLPYRIDINE;130318-01-3;Pyridine,2,3,4-triphenyl-;triphenylpyridine;SCHEMBL996432;DTXSID10534684;AKOS015911310

Chemical Property of 2,3,4-Triphenylpyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 398.982 °C at 760 mmHg
• Flash Point: 169.101 °C
• PSA: 12.89000
• Density: 1.104g/cm³
• LogP: 6.08260
• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 307.136099547
• Heavy Atom Count: 24
• Complexity: 360

Purity/Quality:

99% ^*data from raw suppliers

2,3,4-TRIPHENYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C(=NC=C2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 2,3,4-Triphenylpyridine

There total 8 articles about 2,3,4-Triphenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2-diphenylethanone O-acetyl oxime (19690-01-8) + 3-phenyl-propenal (104-55-2) → 2,3,4-triphenylpyridine (130318-01-3)

Guidance literature:

With iodine; triethylamine; In toluene; at 120 ℃; for 3h; chemoselective reaction;

DOI:10.1021/acs.joc.5b02624

Reference yield: 86.0%

diphenyl acetylene (501-65-5) + N-[(Z)-3-iodo-3-phenylallylidene]-tert-butylamine → 2,3,4-triphenylpyridine (130318-01-3)

Guidance literature:

With zinc; dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); In acetonitrile; at 80 ℃; for 0.333333h;

DOI:10.1021/ol0519994

Reference yield: 85.0%

(E)-1,2-diphenylethan-1-one O-acetyl oxime (128080-52-4) + 3-phenyl-propenal (104-55-2) → 2,3,4-triphenylpyridine (130318-01-3)

Guidance literature:

With copper(l) iodide; diisopropylamine; In dimethyl sulfoxide; at 60 ℃; for 16h; Reagent/catalyst; regioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/ja312346s

upstream raw materials:

N-(1,2-diphenylethenyl)-P,P-diphenylphosphinic amide

3-phenyl-propenal

diphenyl acetylene

(Z)-3-iodo-3-phenylacrylaldehyde

Refernces

• 1、 Huang, Huawen,Cai, Jinhui,Tang, Lichang,Wang, Zilong,Li, Feifei,Deng, Guo-Jun. "Metal-Free Assembly of Polysubstituted Pyridines from Oximes and Acroleins". . p. 1499 - 1505. Retrieved 2016/03/01.
• 2、 Shekarrao, Kommuri,Nath, Dipankar,Kaishap, Partha Pratim,Gogoi, Sanjib,Boruah, Romesh C.. "Palladium-catalyzed multi-component synthesis of steroidal A- and D-ring fused 5,6-disubstituted pyridines under microwave irradiation". . p. 1126 - 1133. Retrieved 2013/10/08.