2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide
CAS No.:1606975-01-2
Molecular Formula:C₂₂H₂₀ClN₃O
Molecular Weight:377.873
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide

There total 8 articles about 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1606975-00-1
methyl 2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetate

: 1606975-01-2
2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide

Guidance literature:: With ammonia; ammonium chloride; In methanol; at 100 ℃; for 69h;

Reference yield:

: 13737-36-5
4-bromophenylacetic acid

: 1606975-01-2
2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: chloro-trimethyl-silane / 2 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere; Sealed tube

4: ammonia; ammonium chloride / methanol / 69 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; ammonia; sodium carbonate; potassium carbonate; ammonium chloride; In 1,4-dioxane; methanol; water;

Reference yield:

: 7398-42-7
methyl 2-(4-(bromomethyl)phenyl)acetate

: 1606975-01-2
2-(4-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere; Sealed tube

3: ammonia; ammonium chloride / methanol / 69 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium carbonate; potassium carbonate; ammonium chloride; In 1,4-dioxane; methanol; water;