diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate

Base Information

Chemical Name:diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate
CAS No.:1420364-16-4
Molecular Formula:C₁₉H₁₇ClF₃NO₅
Molecular Weight:431.796
Hs Code.:

Synonyms:diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate

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Chemical Property of diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate

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Technology Process of diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate

There total 5 articles about diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1420364-12-0
5-(4-chloro-3-(trifluoromethyl)phenoxy)-2-iodopyridine

: 105-53-3
diethyl malonate

: 1420364-16-4
diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate

Guidance literature:: With 2-Picolinic acid; copper(l) iodide; caesium carbonate; In 1,4-dioxane; at 80 ℃; for 10h;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1420364-16-4
diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 10 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 2 h / 80 °C

3: diiodomethane; isopentyl nitrite / 2 h / 80 °C

4: caesium carbonate; 2-Picolinic acid; copper(l) iodide / 1,4-dioxane / 10 h / 80 °C

With 2-Picolinic acid; copper(l) iodide; tin(II) chloride dihdyrate; diiodomethane; potassium carbonate; caesium carbonate; isopentyl nitrite; In 1,4-dioxane; ethanol; acetonitrile;

Reference yield:

: 1420364-02-8
5-(4-chloro-3-(trifluoromethyl)phenoxy)-2-nitropyridine

: 1420364-16-4
diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate / ethanol / 2 h / 80 °C

2: diiodomethane; isopentyl nitrite / 2 h / 80 °C

3: caesium carbonate; 2-Picolinic acid; copper(l) iodide / 1,4-dioxane / 10 h / 80 °C

With 2-Picolinic acid; copper(l) iodide; tin(II) chloride dihdyrate; diiodomethane; caesium carbonate; isopentyl nitrite; In 1,4-dioxane; ethanol;