Morpholin-2-ylmethanol

Base Information

• Chemical Name: Morpholin-2-ylmethanol
• CAS No.: 103003-01-6
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Hs Code.: 2934999090
• European Community (EC) Number: 816-086-5
• DSSTox Substance ID: DTXSID10393056
• Mol file: 103003-01-6.mol

Synonyms:Morpholin-2-ylmethanol;103003-01-6;2-Hydroxymethylmorpholine;(morpholin-2-yl)methanol;2-MORPHOLINEMETHANOL;Morpholin-2-yl-methanol;MFCD03426271;2-(Hydroxymethyl)morpholine;MFCD09260717;(R)-2-HydroxymethylmorpholineHCl;morpholin-2-yl methanol;(S)-2-Morpholinemethanol;2-Hydroxymethyl morpholine;SCHEMBL17137;(S)-morpholin-2-yl)methanol;SCHEMBL3265319;(s)-2-(hydroxymethyl)morpholine;(R)-2-(Hydroxymethyl)morpholine;DTXSID10393056;VLAZLCVSFAYIIL-UHFFFAOYSA-N;(2S)-2-Morpholinemethanol;(2S)-Morpholin-2-ylmethanol;(S)-1-Morpholin-2-ylmethanol;(S)-Morpholin-2-ylmethanol;(S)-Morpholine-2-methanol;BCP14953;METHYL13-METHYLTETRADECANOATE;AB7650;AKOS013153473;hydrochloride;SB15904;SB15905;SB30277;AM802856;BS-12974;SY102185;SY107412;SY129054;CS-0106282;FT-0645861;FT-0650407;FT-0654081;EN300-101373;J-502080;J-502497;Z1235945999

Chemical Property of Morpholin-2-ylmethanol

Chemical Property:

• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.441
• Boiling Point: 220.122 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 86.927 °C
• PSA: 41.49000
• Density: 1.045 g/cm³
• LogP: -0.70410
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

2-Hydroxymethylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)CO
• Uses: 2-Hydroxymethylmorpholine is used to study structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B.

Technology Process of Morpholin-2-ylmethanol

There total 8 articles about Morpholin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

R,S-2-hydroxymethyl-4-benzylmorpholine (40987-24-4,943442-96-4) → morpholin-2-ylmethanol (103003-01-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1248/cpb.33.3766

Reference yield: 26.0%

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (189321-66-2) → morpholin-2-ylmethanol (103003-01-6)

Guidance literature:

With borane; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

Reference yield:

2-hydroxymethyl-4-nosylmorpholine (1542717-38-3) → morpholin-2-ylmethanol (103003-01-6)

Guidance literature:

With 1-thiopropane; lithium hydroxide; In acetonitrile; at 25 ℃; for 8h;

DOI:10.1021/jo500609a

upstream raw materials:

R,S-2-hydroxymethyl-4-benzylmorpholine

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid

C₂₀H₂₁NO₄

2-hydroxymethyl-4-nosylmorpholine

Downstream raw materials:

2-(hydroxymethyl)morpholine hydrochloride

2-Hydroxymethyl-4-benzyloxycarbonyl-morpholine

ethyl 4-(2-bromo-4-fluorophenyl)-6-(((S)-2-(hydroxymethyl)morpholino)methyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Refernces

• 1、 Zhou, Jing,Yeung, Ying-Yeung. "Synthesis of reboxetine intermediate and carnitine acetyltransferase inhibitor via NBS-induced electrophilic multicomponent reaction". . p. 4644 - 4649. Retrieved 2014/06/09.
• 2、 -. "THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS". Page 173. . Retrieved 2008/06/13.