Morpholin-2-ylmethanol hydrochloride

Base Information

• Chemical Name: Morpholin-2-ylmethanol hydrochloride
• CAS No.: 144053-98-5
• Molecular Formula: C₅H₁₁NO₂*ClH
• Molecular Weight: 153.609
• Hs Code.: 2934999090
• European Community (EC) Number: 835-878-1
• DSSTox Substance ID: DTXSID30599816
• Mol file: 144053-98-5.mol

Synonyms:Morpholin-2-ylmethanol hydrochloride;144053-98-5;MORPHOLIN-2-YLMETHANOL HCL;2-Morpholinemethanol, hydrochloride (1:1);morpholin-2-ylmethanol;hydrochloride;2-(Hydroxymethyl)morpholine Hydrochloride;2-Hydroxymethyl-morpholine hydrochloride;MFCD13191721;morpholin-2-yl-methanol hydrochloride;2-Morpholinemethanol HCl;MFCD13191722;(2R)-morpholin-2-ylmethanol hydrochloride;(R)-2-Hydroxymethyl-morpholine hydrochloride;(S)-2-Hydroxymethyl-morpholine hydrochloride;(S)-2-(Hydroxymethyl)morpholine Hydrochloride;SCHEMBL352613;(Morpholin-2-yl)methanol HCl;2-(Hydroxymethyl)morpholine HCl;DTXSID30599816;NBGXGDBTUJNTKJ-UHFFFAOYSA-N;Morpholin-2-ylmethanolhydrochloride;AMY25031;(morpholin-2-yl)methanol hydrochloride;2-hydroxymethylmorpholine hydrochloride;AKOS015919609;CS-W022892;GS-4035;SB15902;SB15903;(2S)-2-Morpholinemethanol hydrochloride;(2R)-2-Morpholinylmethanol hydrochloride;SY024785;SY029745;SY058102;DB-104760;A884833;(Morpholin-2-yl)methanol--hydrogen chloride (1/1)

Chemical Property of Morpholin-2-ylmethanol hydrochloride

Chemical Property:

• PSA: 41.49000
• LogP: 0.09790
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 67.4

Purity/Quality:

99% ^*data from raw suppliers

Morpholin-2-ylmethanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)CO.Cl

Technology Process of Morpholin-2-ylmethanol hydrochloride

There total 7 articles about Morpholin-2-ylmethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate (135065-76-8) → (S)-2-(hydroxymethyl)morpholine hydrochloride (1313584-92-7,144053-98-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃; for 2h;

Reference yield: 94.0%

(2S)-4-(p-tolylsulfinyl)-2-[(trityloxy)methyl]morpholine (1313484-80-8) → (S)-2-(hydroxymethyl)morpholine hydrochloride (1313584-92-7,144053-98-5)

Guidance literature:

(2S)-4-(p-tolylsulfinyl)-2-[(trityloxy)methyl]morpholine; With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With methanol; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/ejoc.201100337

Reference yield:

R,S-2-hydroxymethyl-4-benzylmorpholine (40987-24-4,943442-96-4) → 2-(hydroxymethyl)morpholine hydrochloride (144053-98-5)

Guidance literature:

In hydrogen;

upstream raw materials:

morpholin-2-ylmethanol

tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid

R,S-2-hydroxymethyl-4-benzylmorpholine

Downstream raw materials:

tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate

benzyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

Refernces

• 1、 -. "COMPOUNDS". Paragraph 44. . Retrieved 2018/09/08.
• 2、 -. "COMPOUNDS". Page/Page column 88. . Retrieved 2018/08/20.