2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Base Information

Chemical Name:2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
CAS No.:1420468-32-1
Molecular Formula:C₁₆H₁₄F₃N₃O₂
Molecular Weight:337.301
Hs Code.:

Synonyms:2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

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Chemical Property of 2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

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Technology Process of 2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

There total 4 articles about 2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1420468-31-0,1426098-50-1
5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-3-amine

: 108-59-8
malonic acid dimethyl ester

: 1420468-32-1
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Guidance literature:: With sodium methylate; In methanol; at 20 - 80 ℃; Inert atmosphere;
DOI:10.1021/ml300330m

Reference yield:

: 3-methyl-4-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-5-amine

: 108-59-8
malonic acid dimethyl ester

: 1420468-32-1
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Guidance literature:: With hydrogenchloride; sodium methylate; In methanol;

Reference yield:

: 261952-16-3
1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene

: 1420468-32-1
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 2.5 h / 0 - 40 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 20 - 100 °C / Inert atmosphere

3: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

With sodium methylate; hydrazine hydrate; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml300330m