Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)

Base Information

Chemical Name:Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)
CAS No.:863513-93-3
Molecular Formula:C₂₄H₂₇FN₂O
Molecular Weight:378.49
Hs Code.:
Mol file:863513-93-3.mol

Synonyms:(1s,4s)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

Suppliers and Price of Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Cebranopadol((1α,4α)stereoisomer) 95.60%
5mg
$ 350.00

ChemScene
Cebranopadol((1α,4α)stereoisomer) 95.60%
2mg
$ 190.00

Total 7 raw suppliers

Chemical Property of Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Cebranopadol((1α,4α)stereoisomer) 95.60% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI)

There total 3 articles about Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-aMine, 6'-fluoro-4',9'-dihydro-N,N-diMethyl-4-phenyl-, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: 101349-12-6
2-(5-fluoro-1H-indol-3-yl)ethanol

: 863513-93-3
(1s,4s)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

Guidance literature:: 4-dimethylamino-4-phenylcyclohexanone; 2-(5-fluoro-1H-indol-3-yl)ethanol; With sulfuric acid; In ethanol; at 45 - 60 ℃; for 17h;

With diethylamine; In ethanol; at 20 ℃; Reagent/catalyst; Solvent; Temperature; Time;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 863513-93-3
(1s,4s)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; methanol / 0 - 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

2.2: 0 - 20 °C

3.1: water; hydrogenchloride / diethyl ether

4.1: phosphoric acid; acetic acid / 16 h / 20 °C

With hydrogenchloride; phosphoric acid; water; acetic acid; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/ml500117c

Reference yield:

: 65619-19-4
4-dimethylamino-4-phenylcyclohexanone, ethylene ketal hydrochloride

: 863513-93-3
(1s,4s)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: water; hydrogenchloride / diethyl ether

2: phosphoric acid; acetic acid / 16 h / 20 °C

With hydrogenchloride; phosphoric acid; water; acetic acid; In diethyl ether;
DOI:10.1021/ml500117c