3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid

Base Information

Chemical Name:3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid
CAS No.:1268865-89-9
Molecular Formula:C₂₆H₃₀N₄O₄
Molecular Weight:462.549
Hs Code.:

Synonyms:3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid

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Chemical Property of 3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid

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Technology Process of 3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid

There total 7 articles about 3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1268865-99-1
methyl 3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate

: 74-88-4
methyl iodide

: 1268865-89-9
3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid

Guidance literature:: methyl 3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1268865-89-9
3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

2.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

4.1: phosphorus(V) oxybromide / acetonitrile / Reflux

4.2: pH 7 - 8

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

6.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

6.2: 3 h / 20 °C

With iron; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1268865-89-9
3-(4-(tert-butoxycarbonyl)piperidin-1-yl)-2-phenylquinoxaline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

3.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

5.1: phosphorus(V) oxybromide / acetonitrile / Reflux

5.2: pH 7 - 8

6.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

7.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

7.2: 3 h / 20 °C

With thionyl chloride; iron; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;