(S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

Base Information

Chemical Name:(S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate
CAS No.:1448718-87-3
Molecular Formula:C₂HF₃O₂*C₂₃H₂₉N₇O₆
Molecular Weight:613.551
Hs Code.:

Synonyms:(S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

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Chemical Property of (S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

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Technology Process of (S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

There total 10 articles about (S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (S)-3-(2-(3-(N,N-bis-tert-butoxycarbonylguanidino)-benzoylamino)-acetylamino)-N-[ 4-(3-tertbutoxycarbonylamino-propoxy)-phenyl]-succinamic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1448718-87-3
(S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 623562-63-0
[3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 1448718-87-3
(S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride; zinc / methanol; water

2: di-isopropyl azodicarboxylate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

3: piperidine / tetrahydrofuran / 4 h / 20 °C

4: di-isopropyl azodicarboxylate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: dichloromethane / 0 - 20 °C / Inert atmosphere

With piperidine; di-isopropyl azodicarboxylate; ammonium chloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; zinc; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1448718-83-9
(S)-N-[4-(3-tert-butoxycarbonylamino-propoxy)-phenyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino )-succinamic acid tert-butyl ester

: 1448718-87-3
(S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / tetrahydrofuran / 4 h / 20 °C

2: di-isopropyl azodicarboxylate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: dichloromethane / 0 - 20 °C / Inert atmosphere

With piperidine; di-isopropyl azodicarboxylate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;