3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Base Information

Chemical Name:3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide
CAS No.:1309365-74-9
Molecular Formula:C₂₇H₃₁BrFN₃O₂
Molecular Weight:528.464
Hs Code.:

Synonyms:3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

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Chemical Property of 3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Chemical Property:

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Technology Process of 3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

There total 6 articles about 3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309365-73-8
(E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide

: 1309365-74-9
3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Guidance literature:: With hydrogen; platinum on carbon; In ethanol; for 18h; Product distribution / selectivity;

Reference yield:

: 351-30-4
N-(4-bromo-3-fluorophenyl)ethanamide

: 1309365-74-9
3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice

2.1: ethanol / 2.5 h / 125 °C / Sealed tube

3.1: tetrahydrofuran / 2.5 h / 70 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C

4.2: pH ~ 1

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h

6.1: hydrogen / platinum on carbon / ethanol / 18 h

With water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; platinum on carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol;

Reference yield:

: 1309365-70-5
6-bromo-2-chloro-7-fluoroquinoline-3-carbaldehyde

: 1309365-74-9
3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 2.5 h / 125 °C / Sealed tube

2.1: tetrahydrofuran / 2.5 h / 70 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C

3.2: pH ~ 1

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h

5.1: hydrogen / platinum on carbon / ethanol / 18 h

With water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; platinum on carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol;