Technology Process of 3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide
There total 6 articles about 3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
platinum on carbon;
In
ethanol;
for 18h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichlorophosphate / 48.5 h / 75 °C / Inert atmosphere; Sealed tube; Cooling with ice
2.1: ethanol / 2.5 h / 125 °C / Sealed tube
3.1: tetrahydrofuran / 2.5 h / 70 °C
4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C
4.2: pH ~ 1
5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h
6.1: hydrogen / platinum on carbon / ethanol / 18 h
With
water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate;
platinum on carbon;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ethanol / 2.5 h / 125 °C / Sealed tube
2.1: tetrahydrofuran / 2.5 h / 70 °C
3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.75 h / 20 °C
3.2: pH ~ 1
4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1-methyl-pyrrolidin-2-one / 1 h
5.1: hydrogen / platinum on carbon / ethanol / 18 h
With
water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
platinum on carbon;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol;