351-30-4

Basic information

• Product Name: 4'-BROMO-3'-FLUOROACETANILIDE
• Synonyms: 4'-Bromo-3'-fluoroacetanilide, 98+%;4'-Bromo-3'-fluoroacetanlide;N-(4-Bromo-3-fluorophenyl)acetamide
• CAS NO: 351-30-4
• Molecular Formula: C₈H₇BrFNO
• Molecular Weight: 232.06
• Product Categories: Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds
• Mol File: 351-30-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 149-152°C
• Boiling Point: 337.9°Cat760mmHg
• Flash Point: 158.1°C
• Appearance: /
• Density: 1.623g/cm³
• CAS DataBase Reference: 4'-BROMO-3'-FLUOROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-3'-FLUOROACETANILIDE(351-30-4)
• EPA Substance Registry System: 4'-BROMO-3'-FLUOROACETANILIDE(351-30-4)

Safety Data

• Hazard Codes: Xi
• Statements: 22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 351-30-4(Hazardous Substances Data)

Usage

General Description

4'-Bromo-3'-Fluoroacetanilide, also known as N-(4-bromophenyl)-3-fluoroacetamide, is an organic compound featuring bromine and fluorine in its constituents. It falls under the family of organofluorides and mainly composed of carbon (C), hydrogen (H), nitrogen (N), bromine (Br) and fluorine (F). It is often used in the synthesis of other chemicals and in pharmaceutical applications. It is a solid compound at room temperature and has the potential to harm the eyes, respiratory system, and skin. Safety measures need to be undertaken while handling this chemical to avoid any potential harm.

Upstream product

• 351-28-0 N-(3-fluorophenyl)acetamide 
• 372-19-0 meta-fluoroaniline 
• 656-65-5 3-fluoro-4-bromophenylamine 
• 108-24-7 acetic anhydride 
• 128-08-5 N-Bromosuccinimide 

Downstream Products

• 656-65-5 3-fluoro-4-bromophenylamine 
• 136434-77-0 4-bromo-3-fluoroiodobenzene 
• 136434-78-1 1-bromo-2-fluoro-4-pent-1-ynylbenzene 
• 136434-79-2 1-Bromo-2-fluoro-4-pentylbenzene 
• 1219741-79-3 4-bromo-5-fluoro-2-iodoaniline 
• 1219741-80-6 4-bromo-5-fluoro-2-[(trimethylsilyl)ethynyl]aniline 
• 434960-42-6 5-bromo-6-fluoro-1H-indole 
• 1309364-62-2 3-(2-amino-7-fluoro-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)propanamide 
• 1309365-76-1 N-(cyclohexylmethyl)-3-(7-fluoro-2-(4-methoxybenzylamino)-6-o-tolylquinolin-3-yl)propanamide 
• 1309365-75-0 N-(cyclohexylmethyl)-3-(7-fluoro-2-(4-methoxybenzylamino)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-3-yl)propanamide 
• 1309365-74-9 3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)propanamide 
• 1309365-73-8 (E)-3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(cyclohexylmethyl)acrylamide 
• 1309365-72-7 (E)-methyl 3-(6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinolin-3-yl)acrylate 
• 1309365-71-6 6-bromo-7-fluoro-2-(4-methoxybenzylamino)quinoline-3-carbaldehyde 

Relevant articles and documents

20-HETE FORMATION INHIBITORS

This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain damage by preventing cerebral microvascular blood flow impairment and anti-oxidant mechanisms in a subject experiencing or having experienced an ischemic event.

Combining Eosin y with Selectfluor: A Regioselective Brominating System for Para-Bromination of Aniline Derivatives

A mild, metal-free, and absolutely para-selective bromination of aniline derivatives has been developed in excellent yields, wherein the organic dye Eosin Y is employed as the bromine source in company with Selectfluor. Neither air nor moisture sensitive, this facile reaction proceeds smoothly at room temperature and completes within a short time. Mechanistic studies indicate a radical pathway; therefore, the existence of an in situ generated brominating reagent, "Selectbrom", is postulated, which may reasonably account for the unique regioselectivity for the para-bromination of N-acyl- as well as N-sulfonylanilines.

Anisotropic organic compounds

STR1 The invention describes liquid crystalline compounds or formula (I), where A, D and G are independently selected from phenyl, thiophene, hydrogenated phenyl, chlorinated phenyl and fluorinated phenyl, B and E are independently selected from a single bond C= C. C C.C00, azoxy and diazo, k and m are independently selected from 1 and 0, such that m+n is 1 or 2, and R1 and R2 are independently selected from R, R0, alkynyl, thioalkyl, hydrogen, CN, NCS and SCN; provided that at least one of R1 and R2 is selected from CN, NCS and SCN and that at least one of A, D and G is phenyl; and excluding where at least one of R1 and R2 is independently selected as CN and one of A, D or G is not thiophene, and where m is 0, A, and D are phenyl, B is a single bond and only one of R1 or R2 is NCS. Also described are compounds suitable for inclusion in a device utilizing pretransitional characteristics of liquid crystalline materials in the isotropic phase, of general formula (II) where J and Y are independently selected from phenyl, thiophene, hydrogenated phenyl, chlorinated phenyl and fluorinated phenyl, X is selected from C= C. C C.COO azoxy and diazo, k is 1 or 0 and R3 and R4 are independently selected from R, RO, alkynyl, thioalkyl, hydrogen, CN, NCS and SCN; provided that at least one of R3 and R4 is selected from CN, NCS and SCN and that at least one of J and Y is phenyl.